Filter by year (ZH)
Suggested tags (ZH)
Challenges of developing an ADA assay for bispecific antibody therapeutics and ADA characterisation

博客 - Bispecifics (Bs) are biopharmaceutical products that bind to two different targets (epitopes). These are mainly two types: IgG-like (antibodies Abs) and non-IgG-like which include Bites (bispecific T-cell engager) and DARTs (Dual-affinity Re-targeting Antibody).

Alliance Pharma agrees to acquire LGC’s Drug Development Solutions Business Unit

News (ZH) - Alliance Pharma, a US-based Bioanalytical CRO and an Ampersand portfolio company, has agreed to acquire DDS, a UK-based Bioanalytical Business Unit of LGC. KKR will become an equal shareholder in the combined business alongside Ampersand Capital Partners. Backed by Ampersand and KKR, Alliance and DDS plan to expand the company’s geographic reach, broaden its laboratory capabilities and expand its service portfolio. The transaction is subject to regulatory approvals and expected to be completed in Q2 2022.

Introduction to Pharmacokinetics

博客 - An understanding of the characteristics of drug exposure following administration and how it relates to safety and efficacy is critical for progressing drug development (e.g. in decision making for drug candidates, design of dosing regimens and making predictions for future studies) as well as being a requirement for regulatory authorities. Pharmacokinetics (PK) analysis aims to evaluate quantitatively how a drug enters the body, what happens to the drug while in the body and ultimately, how it is removed. These processes are commonly referred to by the acronym ‘ADME’, which comprises absorption, distribution, metabolism and excretion.

Pharmacokinetics (PK) urine analysis

博客 - Urinary pharmacokinetics (PK) parameters tell you about how much drug was absorbed and how much drug is eliminated

Pharmacokinetics: Area under the curve calculations

博客 - The area under the concentration vs time curve is a useful description of exposure of drug following administration. There are different ways in which AUC may be calculated, and terminology may vary from one source or text to another. This page summarises the calculations and terminology that may be encountered.

The use and applications of PhosphoFlow

博客 - In this infographic, we explore the applications of a flow cytometry-based technique, termed Phosphoflow, for multiplex biomarker analysis and how it can be utilized in a cell-based environment to provide information on a functional and biological level.

Why chemistry-led design brings the greatest value to pharmaceutical development

博客 - Solid form screening and selection: Why chemistry-led design brings the greatest value to pharmaceutical development

The benefits of HRMS compared to QqQ

博客 - This infographic explores top tips to prolong periods between instrument cleans, compare cleaning times for QqQ and QToF platforms and provide an assessment of robustness, with a focus on sensitivity level and mass accuracy. Finally, it presents common trends to be aware of when the QToF platform has become contaminated and requires cleaning.

High Resolution Mass Spectrometry for the CRO

博客 - In this video, we look at the benefits and challenges of high res mass spectrometry for the CRO.