LC-MS Senior Scientist/Principal Scientist

This role is based at Fordham, Cambridgeshire, UK within Drug Development Solutions (DDS).

With one of the world’s largest bioanalytical centres, recognised for leadership in science and technology, DDS has comprehensive capabilities for pharmacokinetic, immunogenicity and biomarker measurement that span LC-MS/MS, immunoassay and flow cytometry. We routinely solve difficult method development challenges and have the capacity to support the largest, most complex protocols. Our Bioanalysis Department works together with pharmaceutical and biopharmaceutical companies in support of pre-clinical and clinical trials for a wide variety of clients and therapeutic areas. We use innovative analytical methodology and the expertise of our analytical scientists to speed up the discovery of new medicines. The Department operates a well-equipped laboratory compliant with GLP and GCP, and offers the opportunity to work with state of the art analytical instrumentation.

The Job (LC-MS Senior Scientist/Principal Scientist)

The focus of this role is scientific leadership and oversight of development and validation activity within LC-MS. You will be responsible for helping us to deliver high quality results to our customers in compliance with GLP/GCP.

Key responsibilities include;

  • Design and develop robust quantitative LC-MS bioanalytical methods in support of PK and PD endpoints
  • Provide expert bioanalytical support in troubleshooting methodologies and instrumentation, minimising downtime and preventing delays in project progression
  • Work with business development and customers to advise on feasibility of supporting new projects
  • Lead implementation of new technologies, techniques, and best practices
  • Critical review of method development and validation projects to ensure progression of high-quality methods, in line with EMA and FDA regulatory guidance on bioanalytical method validation

The ideal candidate will;

  • Be able to lead and mentor scientists
  • Be enthusiastic, proactive, and driven to go the extra mile to support our customers
  • Focus on quality, and possess an excellent attention to detail
  • Communicate effectively to peers and customers alike

Life At Fordham

We have a state of the art purpose built facility within an open green countryside setting, with places to walk and relax outdoors, as well as a café on site. At Fordham, we have friendly collaborative teams, dedicated to helping our customers to achieve their goals. Every day is different; we are empowered to solve a range of scientific problems, and embrace continuous improvement. Individually, and together, we take responsibility to progress projects, learn, and share best practice. We help one another to progress and grow. Together we build strong scientific teams, who celebrate success and make time to have fun.   We take care of our people, environment and community.

Benefits

  • Flexible Working: we offer a flexible approach to work where you can adapt your working pattern to balance your home and work needs
  • Defined career progression, mentoring and support is offered, and personal development is encouraged
  • Excellent training and development opportunities for all employees
  • Wide range of flexible benefits, including a group personal pension plan, access to private medical care, cycle to work scheme, travel insurance and more
  • Regular organised social activities; summer fair, Christmas party, occasional food truck visits and other ad-hoc events and celebrations 

Education, experience and technical skills:

  • Degree in pharmaceutical science, chemistry, biochemistry, biological science, or equivalent relevant laboratory experience
  • Experience in the application of triple quadrupole MS in quantitative bioanalysis. High-resolution MS experience would be desirable
  • Experience in the development of quantitative bioanalytical assays for small molecule drug candidates and/or biomarkers. Protein and peptide experience would be desirable
  • Experience in a GXP accredited laboratory
  • Sound knowledge of EMA and FDA bioanalytical method validation guidelines
  • Experience in the utilisation of liquid handling and/or robotics platforms would be desirable
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