Materials Characterisation

The physical properties of a material will determine how it behaves in terms of processability, flowability, compaction, strength, dissolution, solubility and compatibility. These will effect its safety, efficiency and stability.

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Materials Characterisation

We are highly experienced in the measurement of these properties on a wide range of materials including active ingredients, excipients and formulated products. Our expertise covers all stages of development, registration and manufacturing and we can help you define the optimal solid form and provide critical characterisation over a broad range of attributes.

We support routine measurements, advanced characterisation and troubleshooting, bespoke method development and validation for all stages of the product development and manufacturing pipeline, from our GMP laboratories.

Materials Characterisation

Physico-Chemical

Inverse Gas Chromatography, Dynamic Vapour Sorption and Fourier Transform Infrared Analysis
(Chemical Structure, Surface Energy, Solvent Interaction, Hygroscopicity)

Shape

Particle Image and Electron Microscopy Analysis
(Morphology, Appearance, Sphericity, and Aspect Ratio)

Size

Laser Diffraction and Microscopy Analysis
(Particle Size Distribution)

Surface

Gas Adsorption Analysis
(Specific Surface Area and Porosity)

Crystallinity

Powder X-ray Diffraction and Differential Scanning Calorimetry
(Structure, Polymorphs, Amorphous Content, Solvates, Hydrates, Glass Transition and Melting Point)

Density

Pycnometry, Tap and Bulk
(Relative Volume)

LGC DDS COE Impurity and Contamination

Impurity and Contamination Centre of Excellence

Download PDF - Fact Sheets Card

Materials Characterisation Factsheet

Elemental Impurity & Inorganic Testing

Method Development and Method Validation