Solid Form Screening Services

Understanding the solid form options for an early development candidate is fundamental in supporting progress towards clinical success.

Our comprehensive Materials Science Analysis capability allows us to offer a Solid Form Screening and Selection service for salts, cocrystals and polymorphs.

Our experienced team is able to design and complete efficient screens, interpreting results in the context of candidate development phase and recommending optimal forms for progression.

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DDS Solid Form Screening and Selection Centre of Excellence

Solid Form Screening and Selection Centre of Excellence

Our Solid Form Screening and Selection Centre of Excellence builds on our expertise in Materials Science analysis to offer discovery of high quality crystalline forms of small molecule development candidates.

The centre is supported by expert and experienced materials science analysis using a wide range of analytical techniques operating to the highest quality standards.

Our team has extensive experience in synthetic and medicinal chemistry and will use a chemistry-led approach to design the screening protocols to maximise hit rate while minimising compound requirement. Selected forms will be resynthesized and fully characterised to ensure the smoothest path into the next stage of development.

We can support you with solid form science throughout the drug development process. From candidate selection and efficient large scale synthesis through ‘fit for purpose’ formulation and toxicity studies to scale up, API and formulated drug substance manufacture.

Our Solid Form Screening services:

Salt Screening and Selection in Drug Discovery and Development.

Drug Development Solutions can perform multiple salt screens to improve an active pharmaceutical ingredient (API) or investigational medicinal product (IMP) solid form characteristics, such as solubility, stability, crystallinity, novelty and other processability.

Learn more in our Theory Sheet

Polymorph Screening Services in Pharmaceutical Compounds

The importance of understanding and controlling the crystalline form produced is important. 

Drug Development Solutions can perform multiple crystallization screens to investigate solid-state polymorphism. Using a variety of techniques, we aim to identify and characterize all relevant polymorphic forms as well as any hydrates or solvates of your API.

Learn more in our Theory Sheet

Cocrystal Screening and Selection

At Drug Development Solutions we offer cocrystal screening.

We provide a cocrystal screen for sponsors for a number of reasons, including, Dissolution rate/ solubility,
Crystallinity, Novelty, Hydration issues, Stability, and other processability.

Learn more in our Theory Sheet

Crystallisation Development

Often when an API enters into development the solid form is not crystalline. We offer an extensive crystallisation service to assist you
with your crystallisation and screening and deliver a scalable solution.

Learn more in our Theory Sheet

Solid Form Characterisation

  • Powder X-ray diffraction
  • Differential scanning calorimetry
  • Optical and thermal microscopy
  • Dynamic vapour sorption
  • Thermogravimetric analysis
  • FT-IR
  • NMR

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