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Challenges of developing an ADA assay for bispecific antibody therapeutics and ADA characterisation

Blog - Bispecifics (Bs) are biopharmaceutical products that bind to two different targets (epitopes). These are mainly two types: IgG-like (antibodies Abs) and non-IgG-like which include Bites (bispecific T-cell engager) and DARTs (Dual-affinity Re-targeting Antibody).

24 May 2022
Alliance Pharma agrees to acquire LGC’s Drug Development Solutions Business Unit

News - Alliance Pharma, a US-based Bioanalytical CRO and an Ampersand portfolio company, has agreed to acquire DDS, a UK-based Bioanalytical Business Unit of LGC. KKR will become an equal shareholder in the combined business alongside Ampersand Capital Partners. Backed by Ampersand and KKR, Alliance and DDS plan to expand the company’s geographic reach, broaden its laboratory capabilities and expand its service portfolio. The transaction is subject to regulatory approvals and expected to be completed in Q2 2022.

17 May 2022
Introduction to Pharmacokinetics

Blog - An understanding of the characteristics of drug exposure following administration and how it relates to safety and efficacy is critical for progressing drug development (e.g. in decision making for drug candidates, design of dosing regimens and making predictions for future studies) as well as being a requirement for regulatory authorities. Pharmacokinetics (PK) analysis aims to evaluate quantitatively how a drug enters the body, what happens to the drug while in the body and ultimately, how it is removed. These processes are commonly referred to by the acronym ‘ADME’, which comprises absorption, distribution, metabolism and excretion.

07 January 2022
Pharmacokinetics (PK) urine analysis

Blog - Urinary pharmacokinetics (PK) parameters tell you about how much drug was absorbed and how much drug is eliminated

03 January 2022
Pharmacokinetics: Area under the curve calculations

Blog - The area under the concentration vs time curve is a useful description of exposure of drug following administration. There are different ways in which AUC may be calculated, and terminology may vary from one source or text to another. This page summarises the calculations and terminology that may be encountered.

03 January 2022
The use and applications of PhosphoFlow

Blog - In this infographic, we explore the applications of a flow cytometry-based technique, termed Phosphoflow, for multiplex biomarker analysis and how it can be utilized in a cell-based environment to provide information on a functional and biological level.

12 May 2021
Why chemistry-led design brings the greatest value to pharmaceutical development

Blog - Solid form screening and selection: Why chemistry-led design brings the greatest value to pharmaceutical development

19 April 2021
The benefits of HRMS compared to QqQ

Blog - This infographic explores top tips to prolong periods between instrument cleans, compare cleaning times for QqQ and QToF platforms and provide an assessment of robustness, with a focus on sensitivity level and mass accuracy. Finally, it presents common trends to be aware of when the QToF platform has become contaminated and requires cleaning.

07 April 2021
High Resolution Mass Spectrometry for the CRO

Blog - In this video, we look at the benefits and challenges of high res mass spectrometry for the CRO.

08 January 2021