Blog - An antibody assay was required to detect and quantify IgGs produced against a vaccine. This was required to measure the efficacy and reliability of the vaccine.
01 January 2023Blog - Analytical and Materials Science (AMS) Sandwich Team recently celebrated their 10th Anniversary in an event marking Discovery Park’s 10th Anniversary. AMS Sandwich was founded in 2012 at Discovery Park – Kent’s largest science and innovation park situated just outside of the historic town of Sandwich. The team, initially comprising a few members, was formed with the aim of plugging a gap identified in the ‘Materials Science’ area of pharmaceutical development.
05 December 2022Blog - Based on industry feedback following the recent requirements regarding risk assessments of marketed products, a significant amount of small molecule related APIs, possibly 30%+, have been shown to have the potential to form active related nitrosamines
01 December 2022Blog - AMS Science Lead Mike Ludlow explains the importance of good experimental design for extractable and leachable studies.
10 November 2022Blog - Read our guide ‘A step-by-step guide to developing a robust assay in bioanalysis using LC-MS/MS’ to learn about our proven approach to developing industry-leading LC-MS/MS bioassays.
22 September 2022Blog - What makes a good LC-MS/MS bioassay? When selecting your LC-MS/MS method approach it is worth doing your homework. Pick an assay format that is best suited to your compound and consider factors such as matrix type, analyte structure, choice and availability of reagents, and the sensitivity and specificity you need.
01 September 2022Blog - An understanding of the characteristics of drug exposure following administration and how it relates to safety and efficacy is critical for progressing drug development (e.g. in decision making for drug candidates, design of dosing regimens and making predictions for future studies) as well as being a requirement for regulatory authorities. Pharmacokinetics (PK) analysis aims to evaluate quantitatively how a drug enters the body, what happens to the drug while in the body and ultimately, how it is removed. These processes are commonly referred to by the acronym ‘ADME’, which comprises absorption, distribution, metabolism and excretion.
07 January 2022Blog - Urinary pharmacokinetics (PK) parameters tell you about how much drug was absorbed and how much drug is eliminated
03 January 2022Blog - The area under the concentration vs time curve is a useful description of exposure of drug following administration. There are different ways in which AUC may be calculated, and terminology may vary from one source or text to another. This page summarises the calculations and terminology that may be encountered.
03 January 2022Blog - Meet one of our scientists. Claire is a bioanalytical scientist
06 August 2021